In a large bowl, whisk together buttermilk and hot sauce. Add catfish, tossing to coat. Cover and refrigerate for at least 1 hour or up to overnight.
In a large Dutch oven, pour oil to a depth of 3 inches. Heat over medium heat until a deep-fry thermometer registers 350°.
In a shallow dish, whisk together cornmeal and Creole seasoning.
Remove catfish from bowl, letting excess drip off; discard marinade. Dredge catfish in cornmeal mixture, shaking off excess.
Working in batches, fry catfish until golden brown, 3 to 4 minutes, turning occasionally. Let drain on paper towels. Serve with lemon wedges. Garnish with salt, if desired.
Recipe by Louisiana Cookin' at https://louisianacookin.com/fried-catfish/